Assessing contributions of nucleus accumbens shell subregions to reward-seeking behavior

Highlights • We explored functional heterogeneity across nucleus accumbens shell subregions. • Rats were trained to self-administer cocaine and subsequently extinguished. • Amphetamine microinfusions were targeted to subregions as reinstatement tests. • Targeting the dorsomedial shell led to signifi...

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Veröffentlicht in:	Drug and alcohol dependence 2015-08, Vol.153, p.369-373
Hauptverfasser:	Reed, Michael D, Hildebrand, David G.C, Santangelo, Gabrielle, Moffa, Anthony, Pira, Ashley S, Rycyna, Lisa, Radic, Mia, Price, Katherine, Archbold, Jonathan, McConnell, Kristi, Girard, Lauren, Morin, Kristen, Tang, Anna, Febo, Marcelo, Stellar, James R
Format:	Artikel
Sprache:	eng
Schlagworte:	Amphetamine - administration & dosage Amphetamine - pharmacology Animals Cocaine - administration & dosage Conditioning, Operant - drug effects Conditioning, Operant - physiology Extinction, Psychological - drug effects Extinction, Psychological - physiology Male Microinjections Nucleus Accumbens - anatomy & histology Nucleus Accumbens - physiology Psychiatry Rats Rats, Sprague-Dawley Reward Self Administration
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Zusammenfassung:	Highlights • We explored functional heterogeneity across nucleus accumbens shell subregions. • Rats were trained to self-administer cocaine and subsequently extinguished. • Amphetamine microinfusions were targeted to subregions as reinstatement tests. • Targeting the dorsomedial shell led to significant reinstatement. • No significant reinstatement was observed when targeting the intermediate zone.
ISSN:	0376-8716 1879-0046
DOI:	10.1016/j.drugalcdep.2015.05.001