Antibody and Viral Nucleic Acid Testing of Serum and Cerebrospinal Fluid for Diagnosis of Eastern Equine Encephalitis

Eastern equine encephalitis diagnostic serum antibody can appear 6 days after the onset of symptoms, and its numbers can increase 4-fold in 4 days, arguing for early and frequent serum testing. In populations where cerebrospinal fluid viral nucleic acid testing sensitivity and specificity remain und...

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Veröffentlicht in:	Journal of clinical microbiology 2015-08, Vol.53 (8), p.2768-2772
Hauptverfasser:	Sherwood, James A, Brittain, David C, Howard, John J, Oliver, JoAnne
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Animals Antibodies, Viral - blood Antibodies, Viral - cerebrospinal fluid Case Reports Cerebrospinal Fluid - immunology Child Child, Preschool Encephalomyelitis, Eastern Equine - diagnosis Encephalomyelitis, Eastern Equine - pathology Female Humans Infant Male Middle Aged RNA, Viral - blood RNA, Viral - cerebrospinal fluid Serum - immunology
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Beschreibung
Zusammenfassung:	Eastern equine encephalitis diagnostic serum antibody can appear 6 days after the onset of symptoms, and its numbers can increase 4-fold in 4 days, arguing for early and frequent serum testing. In populations where cerebrospinal fluid viral nucleic acid testing sensitivity and specificity remain undetermined, cerebrospinal antibody testing should also be performed.
ISSN:	0095-1137 1098-660X
DOI:	10.1128/JCM.00647-15