Postnatal TLR2 activation impairs learning and memory in adulthood

Highlights • Neonatal TLR2 activation affects adult cognition in a TLR2-heterodimer specific manner. • Developmental TLR2 deficiency affects multiple cognitive traits in adulthood. • Activation of TLR2/1 and TLR2/6 in neurons exerts differential gene expression.

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Bibliographische Detailangaben
Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2015-08, Vol.48, p.301-312
Hauptverfasser:	Madar, Ravit, Rotter, Aviva, Ben-Asher, Hiba Waldman, Mughal, Mohamed R, Arumugam, Thiruma V, Wood, W.H, Becker, K.G, Mattson, Mark P, Okun, Eitan
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Cognition Conditioning (Psychology) - physiology Exploratory Behavior - physiology Fear - physiology Fear conditioning Hippocampus Learning - physiology Memory - physiology Mice Mice, Knockout Morris water maze Motor Skills - physiology Neurons - metabolism Psychiatry Rotarod Performance Test Spatial learning Spatial Learning - physiology TLR2 Toll-Like Receptor 2 - genetics Toll-Like Receptor 2 - metabolism Toll-like receptors
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Beschreibung
Zusammenfassung:	Highlights • Neonatal TLR2 activation affects adult cognition in a TLR2-heterodimer specific manner. • Developmental TLR2 deficiency affects multiple cognitive traits in adulthood. • Activation of TLR2/1 and TLR2/6 in neurons exerts differential gene expression.
ISSN:	0889-1591 1090-2139
DOI:	10.1016/j.bbi.2015.04.020