Stress sounds the alarmin: The role of the danger-associated molecular pattern HMGB1 in stress-induced neuroinflammatory priming

Highlights • HMGB1 is a danger-associated molecular pattern with unique structure and function. • HMGB1 plays a pivotal role in the pathophysiology of neuroinflammatory conditions. • HMGB1 mediates stress-induced neuroinflammatory priming. • HMGB1 mediated priming may involve the NLRP3 inflammasome....

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Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2015-08, Vol.48, p.1-7
Hauptverfasser:	Frank, Matthew G, Weber, Michael D, Watkins, Linda R, Maier, Steven F
Format:	Artikel
Sprache:	eng
Schlagworte:	Alarmins - metabolism Allergy and Immunology Animals Brain - immunology Brain - metabolism DAMP Glucocorticoid HMGB1 HMGB1 Protein - metabolism Immunity, Innate - physiology Inflammasomes - metabolism Inflammation - immunology Inflammation - metabolism Microglia Neuroinflammation Priming Psychiatry Stress Stress, Physiological - immunology
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Beschreibung
Zusammenfassung:	Highlights • HMGB1 is a danger-associated molecular pattern with unique structure and function. • HMGB1 plays a pivotal role in the pathophysiology of neuroinflammatory conditions. • HMGB1 mediates stress-induced neuroinflammatory priming. • HMGB1 mediated priming may involve the NLRP3 inflammasome. • Glucocorticoids may play a pivotal role in stress- and HMGB1-mediated priming.
ISSN:	0889-1591 1090-2139
DOI:	10.1016/j.bbi.2015.03.010