Effects of age and blood pressure on the retinal arterial wall, analyzed using adaptive optics scanning laser ophthalmoscopy

The wall-to-lumen ratio (WLR) of the vasculature is a promising early marker of retinal microvascular changes. Recently, adaptive optics scanning laser ophthalmoscopy (AOSLO) enabled direct and noninvasive visualization of the arterial wall. Using AOSLO, we analyzed the correlation between age and W...

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Veröffentlicht in:	Scientific reports 2015-07, Vol.5 (1), p.12283-12283, Article 12283
Hauptverfasser:	Arichika, Shigeta, Uji, Akihito, Ooto, Sotaro, Muraoka, Yuki, Yoshimura, Nagahisa
Format:	Artikel
Sprache:	eng
Schlagworte:	639/624/1107/510 692/699/3161 Adult Age Age Factors Aged Arteries Blood Pressure Female Fundus Oculi Humanities and Social Sciences Humans Hypertension Hypertension - physiopathology Lasers Male Microvasculature Middle Aged multidisciplinary Multivariate Analysis Ophthalmoscopy - methods Optics Optics and Photonics - methods Reproducibility of Results Retina Retinal Artery - physiopathology Science Young Adult
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Zusammenfassung:	The wall-to-lumen ratio (WLR) of the vasculature is a promising early marker of retinal microvascular changes. Recently, adaptive optics scanning laser ophthalmoscopy (AOSLO) enabled direct and noninvasive visualization of the arterial wall. Using AOSLO, we analyzed the correlation between age and WLR in 51 normal subjects. In addition, correlations between blood pressure and WLR were analyzed in 73 subjects (51 normal subjects and 22 hypertensive patients). WLR showed a strong correlation with age (r = 0.68, P
ISSN:	2045-2322 2045-2322
DOI:	10.1038/srep12283