A Tutorial on Target‐Mediated Drug Disposition (TMDD) Models

Target‐mediated drug disposition (TMDD) is the phenomenon in which a drug binds with high affinity to its pharmacological target site (such as a receptor) to such an extent that this affects its pharmacokinetic characteristics. The aim of this Tutorial is to provide an introductory guide to the math...

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Veröffentlicht in:	CPT: pharmacometrics and systems pharmacology 2015-06, Vol.4 (6), p.324-337
Hauptverfasser:	Dua, P, Hawkins, E, van der Graaf, PH
Format:	Artikel
Sprache:	eng
Schlagworte:	Growth factors Immunoglobulins Leukemia Ligands Ordinary differential equations Peptides Proteins Tumor necrosis factor-TNF Tutorial
Online-Zugang:	Volltext
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