A Tutorial on Target‐Mediated Drug Disposition (TMDD) Models

A Tutorial on Target‐Mediated Drug Disposition (TMDD) Models

Target‐mediated drug disposition (TMDD) is the phenomenon in which a drug binds with high affinity to its pharmacological target site (such as a receptor) to such an extent that this affects its pharmacokinetic characteristics. The aim of this Tutorial is to provide an introductory guide to the math...

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Veröffentlicht in:CPT: pharmacometrics and systems pharmacology 2015-06, Vol.4 (6), p.324-337
Hauptverfasser: Dua, P, Hawkins, E, van der Graaf, PH
Format: Artikel
Sprache:eng
Schlagworte:
Growth factors
Immunoglobulins
Leukemia
Ligands
Ordinary differential equations
Peptides
Proteins
Tumor necrosis factor-TNF
Tutorial
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Beschreibung
Zusammenfassung:Target‐mediated drug disposition (TMDD) is the phenomenon in which a drug binds with high affinity to its pharmacological target site (such as a receptor) to such an extent that this affects its pharmacokinetic characteristics. The aim of this Tutorial is to provide an introductory guide to the mathematical aspects of TMDD models for pharmaceutical researchers. Examples of Berkeley Madonna code for some models discussed in this Tutorial are provided in the Supplementary Materials.
ISSN:2163-8306
2163-8306
DOI:10.1002/psp4.41