ELMO3 is a novel biomarker for diagnosis and prognosis of non-small cell lung cancer

To investigated the diagnostic and prognostic value of engulfment and cell motility (ELMO3) in non small cell lung cancer (NSCLC). The expression of ELMO3 at mRNA levels were detected using reverse transcription quantitative real-time polymerase chain reaction (qRT-PCR) in 125 NSCLC patients' t...

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Veröffentlicht in:	International journal of clinical and experimental pathology 2015-01, Vol.8 (5), p.5503-5508
Hauptverfasser:	Fan, Wei, Yang, Haikou, Xue, Hong, Sun, Yong, Zhang, Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - blood Adaptor Proteins, Signal Transducing - metabolism Biomarkers, Tumor - metabolism Carcinoma, Non-Small-Cell Lung - blood Carcinoma, Non-Small-Cell Lung - diagnosis Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - pathology Cytoskeletal Proteins - blood Cytoskeletal Proteins - metabolism Female Humans Lung - metabolism Lung - pathology Lung Neoplasms - blood Lung Neoplasms - diagnosis Lung Neoplasms - metabolism Lung Neoplasms - pathology Male Middle Aged Original Prognosis Up-Regulation
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Zusammenfassung:	To investigated the diagnostic and prognostic value of engulfment and cell motility (ELMO3) in non small cell lung cancer (NSCLC). The expression of ELMO3 at mRNA levels were detected using reverse transcription quantitative real-time polymerase chain reaction (qRT-PCR) in 125 NSCLC patients' tissues and adjacent tissues, as well as in the serum of 125 NSCLC patients and 89 healthy controls. Then, receiver operating characteristic curve (ROC), Kaplan-Meier and Cox regression analysis were adopted to estimate the potential diagnostic and prognostic value of ELMO3, respectively. ELMO3 expression level was significantly up-regulated in NSCLC patients' tissues and serum compared with controls (P
ISSN:	1936-2625