Characteristics and kinetics of cervical lymph node regression after radiation therapy for human papillomavirus-associated oropharyngeal carcinoma: Quantitative image analysis of post-radiotherapy response
Summary Background and purpose We sought to characterize the pattern of lymph node regression and morphology following definitive radiation therapy (RT) for human papilloma virus (HPV)-associated oropharyngeal carcinoma in patients with disease control. Materials and methods Radiographically positiv...
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| Veröffentlicht in: | Oral oncology 2015-02, Vol.51 (2), p.195-201 |
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| creator | Tang, Chad Fuller, Clifton D Garden, Adam S Awan, Musaddiq J Colen, Rivka R Morrison, William H Frank, Steven J Beadle, Beth M Phan, Jack Sturgis, Erich M Zafereo, Mark E Weber, Randal S Rosenthal, David I Gunn, G. Brandon |
| description | Summary Background and purpose We sought to characterize the pattern of lymph node regression and morphology following definitive radiation therapy (RT) for human papilloma virus (HPV)-associated oropharyngeal carcinoma in patients with disease control. Materials and methods Radiographically positive cervical lymph nodes from patients treated with definitive RT for HPV-associated oropharyngeal carcinoma were segmented on initial pre- and subsequent post-RT contrast enhanced CT images. Pre-specified quantitative nodal parameters were calculated. Initial nodal parameter correlates of final nodal size, final nodal volume, and time to |
| doi_str_mv | 10.1016/j.oraloncology.2014.11.001 |
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| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4502963</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S1368837514003364</els_id><sourcerecordid>1652380382</sourcerecordid><originalsourceid>FETCH-LOGICAL-c542t-c81c5b7beb5830fabea7da4c282069bea2be54b1aa6e0f0430e9a75a074c4a983</originalsourceid><addsrcrecordid>eNqNUsuO1DAQjBCIXRZ-AVmcuGSwYzuPPayEZnlJKyEEnK2O05nxbGIH2xkpH8k_4exLCydOdsvVVeXuyrI3jG4YZeW7w8Z5GJzVbnC7ZVNQJjaMbShlT7JTVldNTmXDn6Y7L-u85pU8yV6EcKCUSibp8-ykkEIITsVp9nu7Bw86ojchGh0I2I5cG4s3heuJRn80GgYyLOO0J9Z1SDzuPIZgnCXQp1bioTMQ1zru0cO0kN55sp9HsGSCyQyDG-Fo_BxyCMHpBMaOOO-mpL7YHSZ-DV4bm3Dn5NsMNpqYGI9IzAg7TLZgWIK5sTS5EPNV0t2rJTeTswFfZs96GAK-ujvPsp8fP_zYfs6vvn76sn1_lWspipjrmmnZVi22sua0hxah6kDooi5o2aSqaFGKlgGUSHuaJoUNVBJoJbSApuZn2cUt7zS3I3YabUwbUZNPZv2iHBj194s1e7VzRyUkLZqSJ4K3dwTe_ZoxRDWaoHEYwKKbg2KlLHhNeV0k6PktVHsXgsf-QYZRteZBHdTjPKg1D4oxlfKQml8_NvrQeh-ABLi8BWAa19GgV0EbtBo741FH1TnzfzoX_9Dowdg1N9e4YDi42acFpn-pUCiqvq_JXIPJBKWcl4L_AdgK7TQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1652380382</pqid></control><display><type>article</type><title>Characteristics and kinetics of cervical lymph node regression after radiation therapy for human papillomavirus-associated oropharyngeal carcinoma: Quantitative image analysis of post-radiotherapy response</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Tang, Chad ; Fuller, Clifton D ; Garden, Adam S ; Awan, Musaddiq J ; Colen, Rivka R ; Morrison, William H ; Frank, Steven J ; Beadle, Beth M ; Phan, Jack ; Sturgis, Erich M ; Zafereo, Mark E ; Weber, Randal S ; Rosenthal, David I ; Gunn, G. Brandon</creator><creatorcontrib>Tang, Chad ; Fuller, Clifton D ; Garden, Adam S ; Awan, Musaddiq J ; Colen, Rivka R ; Morrison, William H ; Frank, Steven J ; Beadle, Beth M ; Phan, Jack ; Sturgis, Erich M ; Zafereo, Mark E ; Weber, Randal S ; Rosenthal, David I ; Gunn, G. Brandon</creatorcontrib><description>Summary Background and purpose We sought to characterize the pattern of lymph node regression and morphology following definitive radiation therapy (RT) for human papilloma virus (HPV)-associated oropharyngeal carcinoma in patients with disease control. Materials and methods Radiographically positive cervical lymph nodes from patients treated with definitive RT for HPV-associated oropharyngeal carcinoma were segmented on initial pre- and subsequent post-RT contrast enhanced CT images. Pre-specified quantitative nodal parameters were calculated. Initial nodal parameter correlates of final nodal size, final nodal volume, and time to <1 cm short-axis diameter were determined. Results Sixty-six radiographically positive lymph node were analyzed in 36 patients. Lymph nodes exhibited initial volume decreases with size stabilization at ∼4 months. Fifteen nodes (23%) underwent complete radiographic response (median 6.4 months following RT; range 2.9–25.6 months). On multivariate time-to-event analysis, initial hypodense/fat component, nodal volume, and short-axis diameter exhibited inverse association, while higher HU standard deviation exhibited a positive association, with reaching <1 cm short-axis diameter (all p <0.05). Conclusions Our results showed a substantial decrease in nodal volume within the first 1–2 months following RT. These findings support our current nodal imaging paradigm, propose a quantitative methodology, and describe a reference dataset for further validation and comparison studies.</description><identifier>ISSN: 1368-8375</identifier><identifier>EISSN: 1879-0593</identifier><identifier>DOI: 10.1016/j.oraloncology.2014.11.001</identifier><identifier>PMID: 25444304</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Alphapapillomavirus - isolation & purification ; Cervical lymph nodes ; Female ; Hematology, Oncology and Palliative Medicine ; HPV ; Humans ; Lymphatic Metastasis - diagnostic imaging ; Lymphatic Metastasis - radiotherapy ; Male ; Oropharyngeal Neoplasms - pathology ; Oropharyngeal Neoplasms - radiotherapy ; Oropharyngeal Neoplasms - virology ; Oropharynx cancer ; Otolaryngology ; Quantitative methodology ; Radiographic response ; Tomography, X-Ray Computed</subject><ispartof>Oral oncology, 2015-02, Vol.51 (2), p.195-201</ispartof><rights>Elsevier Ltd</rights><rights>2014 Elsevier Ltd</rights><rights>Copyright © 2014 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c542t-c81c5b7beb5830fabea7da4c282069bea2be54b1aa6e0f0430e9a75a074c4a983</citedby><cites>FETCH-LOGICAL-c542t-c81c5b7beb5830fabea7da4c282069bea2be54b1aa6e0f0430e9a75a074c4a983</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.oraloncology.2014.11.001$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25444304$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tang, Chad</creatorcontrib><creatorcontrib>Fuller, Clifton D</creatorcontrib><creatorcontrib>Garden, Adam S</creatorcontrib><creatorcontrib>Awan, Musaddiq J</creatorcontrib><creatorcontrib>Colen, Rivka R</creatorcontrib><creatorcontrib>Morrison, William H</creatorcontrib><creatorcontrib>Frank, Steven J</creatorcontrib><creatorcontrib>Beadle, Beth M</creatorcontrib><creatorcontrib>Phan, Jack</creatorcontrib><creatorcontrib>Sturgis, Erich M</creatorcontrib><creatorcontrib>Zafereo, Mark E</creatorcontrib><creatorcontrib>Weber, Randal S</creatorcontrib><creatorcontrib>Rosenthal, David I</creatorcontrib><creatorcontrib>Gunn, G. Brandon</creatorcontrib><title>Characteristics and kinetics of cervical lymph node regression after radiation therapy for human papillomavirus-associated oropharyngeal carcinoma: Quantitative image analysis of post-radiotherapy response</title><title>Oral oncology</title><addtitle>Oral Oncol</addtitle><description>Summary Background and purpose We sought to characterize the pattern of lymph node regression and morphology following definitive radiation therapy (RT) for human papilloma virus (HPV)-associated oropharyngeal carcinoma in patients with disease control. Materials and methods Radiographically positive cervical lymph nodes from patients treated with definitive RT for HPV-associated oropharyngeal carcinoma were segmented on initial pre- and subsequent post-RT contrast enhanced CT images. Pre-specified quantitative nodal parameters were calculated. Initial nodal parameter correlates of final nodal size, final nodal volume, and time to <1 cm short-axis diameter were determined. Results Sixty-six radiographically positive lymph node were analyzed in 36 patients. Lymph nodes exhibited initial volume decreases with size stabilization at ∼4 months. Fifteen nodes (23%) underwent complete radiographic response (median 6.4 months following RT; range 2.9–25.6 months). On multivariate time-to-event analysis, initial hypodense/fat component, nodal volume, and short-axis diameter exhibited inverse association, while higher HU standard deviation exhibited a positive association, with reaching <1 cm short-axis diameter (all p <0.05). Conclusions Our results showed a substantial decrease in nodal volume within the first 1–2 months following RT. These findings support our current nodal imaging paradigm, propose a quantitative methodology, and describe a reference dataset for further validation and comparison studies.</description><subject>Alphapapillomavirus - isolation & purification</subject><subject>Cervical lymph nodes</subject><subject>Female</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>HPV</subject><subject>Humans</subject><subject>Lymphatic Metastasis - diagnostic imaging</subject><subject>Lymphatic Metastasis - radiotherapy</subject><subject>Male</subject><subject>Oropharyngeal Neoplasms - pathology</subject><subject>Oropharyngeal Neoplasms - radiotherapy</subject><subject>Oropharyngeal Neoplasms - virology</subject><subject>Oropharynx cancer</subject><subject>Otolaryngology</subject><subject>Quantitative methodology</subject><subject>Radiographic response</subject><subject>Tomography, X-Ray Computed</subject><issn>1368-8375</issn><issn>1879-0593</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUsuO1DAQjBCIXRZ-AVmcuGSwYzuPPayEZnlJKyEEnK2O05nxbGIH2xkpH8k_4exLCydOdsvVVeXuyrI3jG4YZeW7w8Z5GJzVbnC7ZVNQJjaMbShlT7JTVldNTmXDn6Y7L-u85pU8yV6EcKCUSibp8-ykkEIITsVp9nu7Bw86ojchGh0I2I5cG4s3heuJRn80GgYyLOO0J9Z1SDzuPIZgnCXQp1bioTMQ1zru0cO0kN55sp9HsGSCyQyDG-Fo_BxyCMHpBMaOOO-mpL7YHSZ-DV4bm3Dn5NsMNpqYGI9IzAg7TLZgWIK5sTS5EPNV0t2rJTeTswFfZs96GAK-ujvPsp8fP_zYfs6vvn76sn1_lWspipjrmmnZVi22sua0hxah6kDooi5o2aSqaFGKlgGUSHuaJoUNVBJoJbSApuZn2cUt7zS3I3YabUwbUZNPZv2iHBj194s1e7VzRyUkLZqSJ4K3dwTe_ZoxRDWaoHEYwKKbg2KlLHhNeV0k6PktVHsXgsf-QYZRteZBHdTjPKg1D4oxlfKQml8_NvrQeh-ABLi8BWAa19GgV0EbtBo741FH1TnzfzoX_9Dowdg1N9e4YDi42acFpn-pUCiqvq_JXIPJBKWcl4L_AdgK7TQ</recordid><startdate>20150201</startdate><enddate>20150201</enddate><creator>Tang, Chad</creator><creator>Fuller, Clifton D</creator><creator>Garden, Adam S</creator><creator>Awan, Musaddiq J</creator><creator>Colen, Rivka R</creator><creator>Morrison, William H</creator><creator>Frank, Steven J</creator><creator>Beadle, Beth M</creator><creator>Phan, Jack</creator><creator>Sturgis, Erich M</creator><creator>Zafereo, Mark E</creator><creator>Weber, Randal S</creator><creator>Rosenthal, David I</creator><creator>Gunn, G. Brandon</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150201</creationdate><title>Characteristics and kinetics of cervical lymph node regression after radiation therapy for human papillomavirus-associated oropharyngeal carcinoma: Quantitative image analysis of post-radiotherapy response</title><author>Tang, Chad ; Fuller, Clifton D ; Garden, Adam S ; Awan, Musaddiq J ; Colen, Rivka R ; Morrison, William H ; Frank, Steven J ; Beadle, Beth M ; Phan, Jack ; Sturgis, Erich M ; Zafereo, Mark E ; Weber, Randal S ; Rosenthal, David I ; Gunn, G. Brandon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c542t-c81c5b7beb5830fabea7da4c282069bea2be54b1aa6e0f0430e9a75a074c4a983</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Alphapapillomavirus - isolation & purification</topic><topic>Cervical lymph nodes</topic><topic>Female</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>HPV</topic><topic>Humans</topic><topic>Lymphatic Metastasis - diagnostic imaging</topic><topic>Lymphatic Metastasis - radiotherapy</topic><topic>Male</topic><topic>Oropharyngeal Neoplasms - pathology</topic><topic>Oropharyngeal Neoplasms - radiotherapy</topic><topic>Oropharyngeal Neoplasms - virology</topic><topic>Oropharynx cancer</topic><topic>Otolaryngology</topic><topic>Quantitative methodology</topic><topic>Radiographic response</topic><topic>Tomography, X-Ray Computed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tang, Chad</creatorcontrib><creatorcontrib>Fuller, Clifton D</creatorcontrib><creatorcontrib>Garden, Adam S</creatorcontrib><creatorcontrib>Awan, Musaddiq J</creatorcontrib><creatorcontrib>Colen, Rivka R</creatorcontrib><creatorcontrib>Morrison, William H</creatorcontrib><creatorcontrib>Frank, Steven J</creatorcontrib><creatorcontrib>Beadle, Beth M</creatorcontrib><creatorcontrib>Phan, Jack</creatorcontrib><creatorcontrib>Sturgis, Erich M</creatorcontrib><creatorcontrib>Zafereo, Mark E</creatorcontrib><creatorcontrib>Weber, Randal S</creatorcontrib><creatorcontrib>Rosenthal, David I</creatorcontrib><creatorcontrib>Gunn, G. Brandon</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Oral oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tang, Chad</au><au>Fuller, Clifton D</au><au>Garden, Adam S</au><au>Awan, Musaddiq J</au><au>Colen, Rivka R</au><au>Morrison, William H</au><au>Frank, Steven J</au><au>Beadle, Beth M</au><au>Phan, Jack</au><au>Sturgis, Erich M</au><au>Zafereo, Mark E</au><au>Weber, Randal S</au><au>Rosenthal, David I</au><au>Gunn, G. Brandon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Characteristics and kinetics of cervical lymph node regression after radiation therapy for human papillomavirus-associated oropharyngeal carcinoma: Quantitative image analysis of post-radiotherapy response</atitle><jtitle>Oral oncology</jtitle><addtitle>Oral Oncol</addtitle><date>2015-02-01</date><risdate>2015</risdate><volume>51</volume><issue>2</issue><spage>195</spage><epage>201</epage><pages>195-201</pages><issn>1368-8375</issn><eissn>1879-0593</eissn><abstract>Summary Background and purpose We sought to characterize the pattern of lymph node regression and morphology following definitive radiation therapy (RT) for human papilloma virus (HPV)-associated oropharyngeal carcinoma in patients with disease control. Materials and methods Radiographically positive cervical lymph nodes from patients treated with definitive RT for HPV-associated oropharyngeal carcinoma were segmented on initial pre- and subsequent post-RT contrast enhanced CT images. Pre-specified quantitative nodal parameters were calculated. Initial nodal parameter correlates of final nodal size, final nodal volume, and time to <1 cm short-axis diameter were determined. Results Sixty-six radiographically positive lymph node were analyzed in 36 patients. Lymph nodes exhibited initial volume decreases with size stabilization at ∼4 months. Fifteen nodes (23%) underwent complete radiographic response (median 6.4 months following RT; range 2.9–25.6 months). On multivariate time-to-event analysis, initial hypodense/fat component, nodal volume, and short-axis diameter exhibited inverse association, while higher HU standard deviation exhibited a positive association, with reaching <1 cm short-axis diameter (all p <0.05). Conclusions Our results showed a substantial decrease in nodal volume within the first 1–2 months following RT. These findings support our current nodal imaging paradigm, propose a quantitative methodology, and describe a reference dataset for further validation and comparison studies.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>25444304</pmid><doi>10.1016/j.oraloncology.2014.11.001</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Oral oncology, 2015-02, Vol.51 (2), p.195-201 |
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| subjects | Alphapapillomavirus - isolation & purification Cervical lymph nodes Female Hematology, Oncology and Palliative Medicine HPV Humans Lymphatic Metastasis - diagnostic imaging Lymphatic Metastasis - radiotherapy Male Oropharyngeal Neoplasms - pathology Oropharyngeal Neoplasms - radiotherapy Oropharyngeal Neoplasms - virology Oropharynx cancer Otolaryngology Quantitative methodology Radiographic response Tomography, X-Ray Computed |
| title | Characteristics and kinetics of cervical lymph node regression after radiation therapy for human papillomavirus-associated oropharyngeal carcinoma: Quantitative image analysis of post-radiotherapy response |
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