Characteristics and kinetics of cervical lymph node regression after radiation therapy for human papillomavirus-associated oropharyngeal carcinoma: Quantitative image analysis of post-radiotherapy response

Summary Background and purpose We sought to characterize the pattern of lymph node regression and morphology following definitive radiation therapy (RT) for human papilloma virus (HPV)-associated oropharyngeal carcinoma in patients with disease control. Materials and methods Radiographically positiv...

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Veröffentlicht in:Oral oncology 2015-02, Vol.51 (2), p.195-201
Hauptverfasser: Tang, Chad, Fuller, Clifton D, Garden, Adam S, Awan, Musaddiq J, Colen, Rivka R, Morrison, William H, Frank, Steven J, Beadle, Beth M, Phan, Jack, Sturgis, Erich M, Zafereo, Mark E, Weber, Randal S, Rosenthal, David I, Gunn, G. Brandon
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Sprache:eng
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Zusammenfassung:Summary Background and purpose We sought to characterize the pattern of lymph node regression and morphology following definitive radiation therapy (RT) for human papilloma virus (HPV)-associated oropharyngeal carcinoma in patients with disease control. Materials and methods Radiographically positive cervical lymph nodes from patients treated with definitive RT for HPV-associated oropharyngeal carcinoma were segmented on initial pre- and subsequent post-RT contrast enhanced CT images. Pre-specified quantitative nodal parameters were calculated. Initial nodal parameter correlates of final nodal size, final nodal volume, and time to
ISSN:1368-8375
1879-0593
DOI:10.1016/j.oraloncology.2014.11.001