Dendritic protein synthesis in the normal and diseased brain

Highlights ► Locally synthesized proteins have diverse functions at the synapse. ► RNA binding proteins cooperatively regulate dendritic protein synthesis. ► Local protein synthesis regulates neuronal function outside the hippocampus. ► Varied neurological disorders may involve dysregulated local pr...

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Veröffentlicht in:	Neuroscience 2013-03, Vol.232, p.106-127
Hauptverfasser:	Swanger, S.A, Bassell, G.J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain - physiology Brain - physiopathology Brain Diseases - physiopathology Dendrites - metabolism dendritic protein synthesis Humans mRNA localization neurological disease Neurology Neuronal Plasticity - physiology Protein Biosynthesis - physiology RNA Transport - physiology RNA, Messenger - metabolism Synapses - physiology synaptic plasticity
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Zusammenfassung:	Highlights ► Locally synthesized proteins have diverse functions at the synapse. ► RNA binding proteins cooperatively regulate dendritic protein synthesis. ► Local protein synthesis regulates neuronal function outside the hippocampus. ► Varied neurological disorders may involve dysregulated local protein synthesis.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2012.12.003