INPP4B Is a Tumor Suppressor in the Context of PTEN Deficiency

Enzymes (PI3K and PTEN) controlling cellular levels of 3-phosphorylated phosphoinositides are known as important drivers or suppressors of tumorigenesis in various cancers. In this issue of Cancer Discovery, Kofuji and colleagues and Chew and colleagues identify the lipid phosphatase INPP4B as a con...

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Veröffentlicht in:	Cancer discovery 2015-07, Vol.5 (7), p.697-700
Hauptverfasser:	Vo, Thanh-Trang T, Fruman, David A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma, Follicular - pathology Animals Female Humans Lung Neoplasms - metabolism Male Phosphatidylinositol 3-Kinases - metabolism Phosphatidylinositol Phosphates - metabolism Phosphoric Monoester Hydrolases - metabolism Proto-Oncogene Proteins c-akt - metabolism PTEN Phosphohydrolase - deficiency Thyroid Neoplasms - metabolism Thyroid Neoplasms - pathology
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Beschreibung
Zusammenfassung:	Enzymes (PI3K and PTEN) controlling cellular levels of 3-phosphorylated phosphoinositides are known as important drivers or suppressors of tumorigenesis in various cancers. In this issue of Cancer Discovery, Kofuji and colleagues and Chew and colleagues identify the lipid phosphatase INPP4B as a context-specific tumor suppressor that controls phosphoinositide levels and AKT2 activation in PTEN-deficient cells.
ISSN:	2159-8274 2159-8290
DOI:	10.1158/2159-8290.cd-15-0609