Primaquine dosing errors: the human cost of a pharmaceutical anachronism

Primaquine dosing errors: the human cost of a pharmaceutical anachronism

Confusion between salt/base forms of primaquine may result in malaria prophylaxis failure. During 1995-2011, there were 14 malaria cases in Israel despite primaquine primary prophylaxis. In 6/14 cases, primaquine was underdosed because of confusion between salt and base forms, including two Plasmodi...

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Veröffentlicht in:The American journal of tropical medicine and hygiene 2015-07, Vol.93 (1), p.123-124
Hauptverfasser: Meltzer, Eyal, Morrison, Lindsay, Stienlauf, Shmuel, Schwartz, Eli
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Antimalarials - administration & dosage
Chemoprevention
Cohort Studies
Dosage Forms
Female
Humans
Israel
Malaria, Falciparum - prevention & control
Malaria, Vivax - prevention & control
Male
Medication Errors
Plasmodium falciparum
Primaquine - administration & dosage
Retrospective Studies
Young Adult
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Beschreibung
Zusammenfassung:Confusion between salt/base forms of primaquine may result in malaria prophylaxis failure. During 1995-2011, there were 14 malaria cases in Israel despite primaquine primary prophylaxis. In 6/14 cases, primaquine was underdosed because of confusion between salt and base forms, including two Plasmodium falciparum cases. Primaquine labeling clarification may be lifesaving.
ISSN:0002-9637
1476-1645
DOI:10.4269/ajtmh.14-0109