Dopamine-dependent corticostriatal synaptic filtering regulates sensorimotor behavior

Highlights • Corticostriatal synaptic filtering is absent following dopamine lesion. • Filtering is not reinstated by l -DOPA or D2 agonist, which overactivate behavior. • With a CB1 receptor antagonist, l -DOPA or D2 agonists normalize synaptic filtering and behavior. • Filtering by D2, mGlu-R5 , a...

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Veröffentlicht in:	Neuroscience 2015-04, Vol.290, p.594-607
Hauptverfasser:	Wong, M.Y, Borgkvist, A, Choi, S.J, Mosharov, E.V, Bamford, N.S, Sulzer, D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cerebral Cortex - drug effects Cerebral Cortex - physiopathology Corpus Striatum - drug effects Corpus Striatum - physiopathology corticostriatal dopamine Dopamine - metabolism Dopamine Agents - pharmacology l-DOPA Levodopa - pharmacology Mice, Inbred C57BL Motor Activity - drug effects Motor Activity - physiology Neural Pathways - drug effects Neural Pathways - physiopathology Neurology Oxidopamine Parkinsonian Disorders - drug therapy Parkinsonian Disorders - physiopathology Parkinson’s Receptor, Cannabinoid, CB1 - antagonists & inhibitors Receptor, Cannabinoid, CB1 - metabolism Receptor, Metabotropic Glutamate 5 - metabolism Receptors, Dopamine D2 - agonists Receptors, Dopamine D2 - metabolism synapses Synapses - drug effects Synapses - physiology Tissue Culture Techniques
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Zusammenfassung:	Highlights • Corticostriatal synaptic filtering is absent following dopamine lesion. • Filtering is not reinstated by l -DOPA or D2 agonist, which overactivate behavior. • With a CB1 receptor antagonist, l -DOPA or D2 agonists normalize synaptic filtering and behavior. • Filtering by D2, mGlu-R5 , and CB1 receptors is required for normal sensorimotor behavior.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2015.01.022