Brain Genomics Superstruct Project initial data release with structural, functional, and behavioral measures

The goal of the Brain Genomics Superstruct Project (GSP) is to enable large-scale exploration of the links between brain function, behavior, and ultimately genetic variation. To provide the broader scientific community data to probe these associations, a repository of structural and functional magnetic resonance imaging (MRI) scans linked to genetic information was constructed from a sample of healthy individuals. The initial release, detailed in the present manuscript, encompasses quality screened cross-sectional data from 1,570 participants ages 18 to 35 years who were scanned with MRI and completed demographic and health questionnaires. Personality and cognitive measures were obtained on a subset of participants. Each dataset contains a T1-weighted structural MRI scan and either one ( n =1,570) or two ( n =1,139) resting state functional MRI scans. Test-retest reliability datasets are included from 69 participants scanned within six months of their initial visit. For the majority of participants self-report behavioral and cognitive measures are included ( n =926 and n =892 respectively). Analyses of data quality, structure, function, personality, and cognition are presented to demonstrate the dataset’s utility. Design Type(s) time series design • Observational Study • Test-retest Reliability Measurement Type(s) nuclear magnetic resonance assay • Personality Traits Technology Type(s) MRI Scanner • Patient Self-Report Factor Type(s) Sample Characteristic(s) Homo sapiens • brain Machine-accessible metadata file describing the reported data (ISA-Tab format)