Innate immunity at mucosal surfaces: the IRE1-RIDD-RIG-I pathway

Highlights • IRE1 signals in innate immunity by producing mRNA fragments that activate RIG-I. • Genetic defects in regulation of the IRE1–RIG-I pathway induce IFNs in humans. • The pathway may be uniquely amplified at mucosal surfaces by expression of IRE1β. • IRE1 may function as both a guard recep...

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Veröffentlicht in:	Trends in immunology 2015-07, Vol.36 (7), p.401-409
Hauptverfasser:	Lencer, Wayne I, DeLuca, Heidi, Grey, Michael J, Cho, Jin Ah
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology DEAD Box Protein 58 DEAD-box RNA Helicases - immunology Endoplasmic Reticulum - immunology Endoribonucleases - immunology Gene expression Homeostasis Humans Hypotheses Immunity, Innate Immunity, Mucosal inflammation innate immunity intestine IRE1 Kinases Laboratories mucosal immunity Mucous Membrane - immunology Pattern recognition Protein folding Protein Serine-Threonine Kinases - immunology Protein synthesis Receptors, Immunologic RIG-I Rodents Stress response Surface Properties Surveillance
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Beschreibung
Zusammenfassung:	Highlights • IRE1 signals in innate immunity by producing mRNA fragments that activate RIG-I. • Genetic defects in regulation of the IRE1–RIG-I pathway induce IFNs in humans. • The pathway may be uniquely amplified at mucosal surfaces by expression of IRE1β. • IRE1 may function as both a guard receptor, responding to cell stress, and a direct PRR. • Innate immune pathways may survey the ER for signals of the presence of pathogens.
ISSN:	1471-4906 1471-4981
DOI:	10.1016/j.it.2015.05.006