Inflammatory reaction after traumatic brain injury: therapeutic potential of targeting cell–cell communication by chemokines

Highlights • The inflammatory reaction after TBI follows a stereotyped time course. • Multiple cellular and molecular mediators may contribute to secondary injury. • Chemokines mediate peripheral immune cell recruitment after TBI. • Chemokine pathways are altered after TBI and may represent therapeu...

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Veröffentlicht in:	Trends in pharmacological sciences (Regular ed.) 2015-07, Vol.36 (7), p.471-480
Hauptverfasser:	Gyoneva, Stefka, Ransohoff, Richard M
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science Animals Astrocytes - immunology Brain Injuries - immunology Brain Injuries - metabolism Brain Injuries - pathology Brain Injuries - therapy CCR2 Cell Communication - immunology chemokines Chemokines - immunology Chemokines - metabolism Disease Models, Animal Humans inflammation Microglia - immunology Receptors, Chemokine - immunology Receptors, Chemokine - metabolism Signal Transduction traumatic brain injury
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Beschreibung
Zusammenfassung:	Highlights • The inflammatory reaction after TBI follows a stereotyped time course. • Multiple cellular and molecular mediators may contribute to secondary injury. • Chemokines mediate peripheral immune cell recruitment after TBI. • Chemokine pathways are altered after TBI and may represent therapeutic targets.
ISSN:	0165-6147 1873-3735
DOI:	10.1016/j.tips.2015.04.003