Balanced UTE-SSFP for 19F MR imaging of complex spectra

Purpose A novel technique for highly sensitive detection of multiresonant fluorine imaging agents was designed and tested with the use of dual‐frequency 19F/1H ultrashort echo times (UTE) sampled with a balanced steady‐state free precession (SSFP) pulse sequence and three‐dimensional (3D) radial rea...

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Veröffentlicht in:Magnetic resonance in medicine 2015-08, Vol.74 (2), p.537-543
Hauptverfasser: Goette, Matthew J., Keupp, Jochen, Rahmer, Jürgen, Lanza, Gregory M., Wickline, Samuel A., Caruthers, Shelton D.
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Sprache:eng
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Zusammenfassung:Purpose A novel technique for highly sensitive detection of multiresonant fluorine imaging agents was designed and tested with the use of dual‐frequency 19F/1H ultrashort echo times (UTE) sampled with a balanced steady‐state free precession (SSFP) pulse sequence and three‐dimensional (3D) radial readout. Methods Feasibility of 3D radial balanced UTE‐SSFP imaging was demonstrated for a phantom comprising liquid perfluorooctyl bromide (PFOB). Sensitivity of the pulse sequence was measured and compared with other sequences imaging the PFOB (CF2)6 line group including UTE radial gradient‐echo (GRE) at α = 30°, as well as Cartesian GRE, balanced SSFP, and fast spin‐echo (FSE). The PFOB CF3 peak was also sampled with FSE. Results The proposed balanced UTE‐SSFP technique exhibited a relative detection sensitivity of 51 μmolPFOB−1min−1/2 (α = 30°), at least twice that of other sequence types with either 3D radial (UTE GRE: 20 μmolPFOB−1min−1/2) or Cartesian k‐space filling (GRE: 12 μmolPFOB−1min−1/2; FSE: 16 μmolPFOB−1min−1/2; balanced SSFP: 23 μmolPFOB−1min−1/2). In vivo imaging of angiogenesis‐targeted PFOB nanoparticles was demonstrated in a rabbit model of cancer on a clinical 3 Tesla scanner. Conclusion A new dual 19F/1H balanced UTE‐SSFP sequence manifests high SNR, with detection sensitivity more than two‐fold better than traditional techniques, and alleviates imaging problems caused by dephasing in complex spectra. Magn Reson Med 74:537–543, 2015. © 2014 Wiley Periodicals, Inc.
ISSN:0740-3194
1522-2594
DOI:10.1002/mrm.25437