Balanced UTE-SSFP for 19F MR imaging of complex spectra
Purpose A novel technique for highly sensitive detection of multiresonant fluorine imaging agents was designed and tested with the use of dual‐frequency 19F/1H ultrashort echo times (UTE) sampled with a balanced steady‐state free precession (SSFP) pulse sequence and three‐dimensional (3D) radial rea...
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Veröffentlicht in: | Magnetic resonance in medicine 2015-08, Vol.74 (2), p.537-543 |
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Zusammenfassung: | Purpose
A novel technique for highly sensitive detection of multiresonant fluorine imaging agents was designed and tested with the use of dual‐frequency 19F/1H ultrashort echo times (UTE) sampled with a balanced steady‐state free precession (SSFP) pulse sequence and three‐dimensional (3D) radial readout.
Methods
Feasibility of 3D radial balanced UTE‐SSFP imaging was demonstrated for a phantom comprising liquid perfluorooctyl bromide (PFOB). Sensitivity of the pulse sequence was measured and compared with other sequences imaging the PFOB (CF2)6 line group including UTE radial gradient‐echo (GRE) at α = 30°, as well as Cartesian GRE, balanced SSFP, and fast spin‐echo (FSE). The PFOB CF3 peak was also sampled with FSE.
Results
The proposed balanced UTE‐SSFP technique exhibited a relative detection sensitivity of 51
μmolPFOB−1min−1/2 (α = 30°), at least twice that of other sequence types with either 3D radial (UTE GRE: 20
μmolPFOB−1min−1/2) or Cartesian k‐space filling (GRE: 12
μmolPFOB−1min−1/2; FSE: 16
μmolPFOB−1min−1/2; balanced SSFP: 23
μmolPFOB−1min−1/2). In vivo imaging of angiogenesis‐targeted PFOB nanoparticles was demonstrated in a rabbit model of cancer on a clinical 3 Tesla scanner.
Conclusion
A new dual 19F/1H balanced UTE‐SSFP sequence manifests high SNR, with detection sensitivity more than two‐fold better than traditional techniques, and alleviates imaging problems caused by dephasing in complex spectra. Magn Reson Med 74:537–543, 2015. © 2014 Wiley Periodicals, Inc. |
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ISSN: | 0740-3194 1522-2594 |
DOI: | 10.1002/mrm.25437 |