Respiratory Syncytial Virus Genomic Load and Disease Severity Among Children Hospitalized With Bronchiolitis: Multicenter Cohort Studies in the United States and Finland

Background. We investigated whether children with a higher respiratory syncytial virus (RSV) genomic load are at a higher risk of more-severe bronchiolitis. Methods. Two multicenter prospective cohort studies in the United States and Finland used the same protocol to enroll children aged

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Bibliographische Detailangaben
Veröffentlicht in:	The Journal of infectious diseases 2015-05, Vol.211 (10), p.1550-1559
Hauptverfasser:	Hasegawa, Kohei, Jartti, Tuomas, Mansbach, Jonathan M., Laham, Federico R., Jewell, Alan M., Espinola, Janice A., Piedra, Pedro A., Camargo, Carlos A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Bronchiolitis - pathology Bronchiolitis - veterinary Child, Preschool Cohort Studies Critical Care - utilization Female Finland Humans Infant Length of Stay Major and Brief Reports Male Nasopharynx - virology Prospective Studies Real-Time Polymerase Chain Reaction Respiration, Artificial - utilization Respiratory syncytial virus Respiratory Syncytial Virus Infections - pathology Respiratory Syncytial Virus Infections - virology Respiratory Syncytial Virus, Human - genetics Respiratory Syncytial Virus, Human - isolation & purification RNA, Viral - analysis RNA, Viral - genetics Statistics as Topic United States Viral Load VIRUSES
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Zusammenfassung:	Background. We investigated whether children with a higher respiratory syncytial virus (RSV) genomic load are at a higher risk of more-severe bronchiolitis. Methods. Two multicenter prospective cohort studies in the United States and Finland used the same protocol to enroll children aged
ISSN:	0022-1899 1537-6613
DOI:	10.1093/infdis/jiu658