Heart rate variability predicts levels of inflammatory markers: Evidence for the vagal anti-inflammatory pathway

Highlights • We examine relationships between heart rate variability and 6 inflammatory markers. • Our sample is from the large, nationally representative MIDUS II study. • We adjusted for urinary norepinephrine and a wide range of covariates. • Significant inverse relationships existed between HRV...

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Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2015-10, Vol.49, p.94-100
Hauptverfasser:	Cooper, Timothy M, McKinley, Paula S, Seeman, Teresa E, Choo, Tse-Hwei, Lee, Seonjoo, Sloan, Richard P
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Biomarkers - blood Biomarkers - urine C-Reactive Protein - metabolism Female Fibrinogen - metabolism Heart Rate Heart rate variability Humans Inflammation Inflammation - metabolism Inflammation Mediators - metabolism Interleukin-6 - blood Male Middle Aged Norepinephrine - urine Psychiatry Sex Factors Sympathetic Nervous System - metabolism Urinary norepinephrine Vagal anti-inflammatory pathway Vagus Nerve - physiology
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Beschreibung
Zusammenfassung:	Highlights • We examine relationships between heart rate variability and 6 inflammatory markers. • Our sample is from the large, nationally representative MIDUS II study. • We adjusted for urinary norepinephrine and a wide range of covariates. • Significant inverse relationships existed between HRV and 3 inflammatory markers. • We did not observe consistent sex differences in these relationships.
ISSN:	0889-1591 1090-2139
DOI:	10.1016/j.bbi.2014.12.017