Rare Copy Number Variants: A Point of Rarity in Genetic Risk for Bipolar Disorder and Schizophrenia

Rare Copy Number Variants: A Point of Rarity in Genetic Risk for Bipolar Disorder and Schizophrenia

CONTEXT Recent studies suggest that copy number variation in the human genome is extensive and may play an important role in susceptibility to disease, including neuropsychiatric disorders such as schizophrenia and autism. The possible involvement of copy number variants (CNVs) in bipolar disorder h...

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Veröffentlicht in:Archives of general psychiatry 2010-04, Vol.67 (4), p.318-327
Hauptverfasser: Grozeva, Detelina, Kirov, George, Ivanov, Dobril, Jones, Ian R, Jones, Lisa, Green, Elaine K, St Clair, David M, Young, Allan H, Ferrier, Nicol, Farmer, Anne E, McGuffin, Peter, Holmans, Peter A, Owen, Michael J, O’Donovan, Michael C, Craddock, Nick
Format: Artikel
Sprache:eng
Schlagworte:
Adult and adolescent clinical studies
Biological and medical sciences
Bipolar Disorder - genetics
Bipolar disorders
DNA Copy Number Variations - genetics
Genetic Predisposition to Disease - genetics
Genome-Wide Association Study
Genotype
Humans
Medical sciences
Mood disorders
Oligonucleotide Array Sequence Analysis
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Risk Factors
Schizophrenia - genetics
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Zusammenfassung:CONTEXT Recent studies suggest that copy number variation in the human genome is extensive and may play an important role in susceptibility to disease, including neuropsychiatric disorders such as schizophrenia and autism. The possible involvement of copy number variants (CNVs) in bipolar disorder has received little attention to date. OBJECTIVES To determine whether large (>100 000 base pairs) and rare (found in
ISSN:0003-990X
1538-3636
DOI:10.1001/archgenpsychiatry.2010.25