First-Trimester Serum Acylcarnitine Levels to Predict Preeclampsia: A Metabolomics Approach

First-Trimester Serum Acylcarnitine Levels to Predict Preeclampsia: A Metabolomics Approach

Objective. To expand the search for preeclampsia (PE) metabolomics biomarkers through the analysis of acylcarnitines in first-trimester maternal serum. Methods. This was a nested case-control study using serum from pregnant women, drawn between 8 and 14 weeks of gestational age. Metabolites were mea...

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Veröffentlicht in:Disease markers 2015-01, Vol.2015 (2015), p.1-8
Hauptverfasser: Pennings, Jeroen L. A., Visser, Gerard H. A., Hankemeier, Thomas, Schielen, Peter C. J. I., Kuc, Sylwia, Dane, Adrie D., Harms, Amy C., Vreeken, Rob J., Koster, Maria P. H., Berger, Ruud
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Biomarkers - blood
Carnitine
Carnitine - analogs & derivatives
Carnitine - blood
Case-Control Studies
Female
Genetic aspects
Health aspects
Humans
Innovations
Metabolomics
Metabolomics - methods
Pre-Eclampsia - blood
Pre-Eclampsia - diagnosis
Preeclampsia
Pregnancy
Pregnancy Trimester, First - blood
Risk factors
Tandem Mass Spectrometry
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Beschreibung
Zusammenfassung:Objective. To expand the search for preeclampsia (PE) metabolomics biomarkers through the analysis of acylcarnitines in first-trimester maternal serum. Methods. This was a nested case-control study using serum from pregnant women, drawn between 8 and 14 weeks of gestational age. Metabolites were measured using an UPLC-MS/MS based method. Concentrations were compared between controls ( n = 500 ) and early-onset- (EO-) PE ( n = 68 ) or late-onset- (LO-) PE ( n = 99 ) women. Metabolites with a false discovery rate
ISSN:0278-0240
1875-8630
DOI:10.1155/2015/857108