Reply to Farkouh RA et al. Comment on “Cost-Effectiveness Evaluation of the 10-Valent Pneumococcal Non-Typeable Haemophilus Influenzae Protein D Conjugate Vaccine and 13-Valent Pneumococcal Vaccine in Japanese Children”

Pneumococcal Non-typeable Haemophilus influenzae Protein D Conjugate Vaccine and 13-Valent Pneumococcal Vaccine in Japanese Children raise questions concerning the efficacy and effectiveness assumptions made for both vaccines. We agree with Farkouh et al that the validity of any cost-effectiveness model relies upon both the ability of the model to reflect the reality of complex clinical and epidemiological scenarios and the quality of the input data.