Preparation of Potassium Alkoxymethyltrifluoroborates and Their Cross-Coupling with Aryl Chlorides

Preparation of Potassium Alkoxymethyltrifluoroborates and Their Cross-Coupling with Aryl Chlorides

A wide variety of alkoxymethyltrifluoroborate substrates were prepared via SN2 displacement of potassium bromomethyltrifluoroborate with various alkoxides in excellent yields. These alkoxymethyltrifluoroborates were effectively cross-coupled with several aryl chlorides. This method provides a unique...

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Veröffentlicht in:Organic letters 2008-06, Vol.10 (11), p.2135-2138
Hauptverfasser: Molander, Gary A, Canturk, Belgin
Format: Artikel
Sprache:eng
Schlagworte:
Borates - chemical synthesis
Borates - chemistry
Chlorides - chemistry
Potassium - chemistry
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Zusammenfassung:A wide variety of alkoxymethyltrifluoroborate substrates were prepared via SN2 displacement of potassium bromomethyltrifluoroborate with various alkoxides in excellent yields. These alkoxymethyltrifluoroborates were effectively cross-coupled with several aryl chlorides. This method provides a unique dissonant disconnect that allows greater flexibility in the design of new and improved synthetic pathways.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol800532p