Dendritic cells change IL-27 production pattern during childhood
Interleukin-27 (IL-27) has been described to be highly expressed during the very first days after birth, but secretion of IL-27 by dendritic cells during the course of childhood has not been described. In our present study we enrolled children (n = 55) in the range from 1 day of to 18 years of age a...
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Veröffentlicht in: | BMC research notes 2015-06, Vol.8 (1), p.232-232, Article 232 |
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Sprache: | eng |
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Zusammenfassung: | Interleukin-27 (IL-27) has been described to be highly expressed during the very first days after birth, but secretion of IL-27 by dendritic cells during the course of childhood has not been described.
In our present study we enrolled children (n = 55) in the range from 1 day of to 18 years of age and asked for a small whole blood sample. The capacity of dendritic cells to produce IL-27 during childhood was measured after whole blood culture with or without inflammatory stimuli. Results support recent findings of high IL-27 levels after birth and lowest levels in adults. Interestingly, we detected an interim peak production level at early adolescence.
These data hint to prominent roles of IL-27 at the very start of post-natal life. Furthermore, a link has been given to so far not described immunological events during puberty. |
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ISSN: | 1756-0500 1756-0500 |
DOI: | 10.1186/s13104-015-1182-0 |