Overexpression of DNA methyltransferase 1 as a negative independent prognostic factor in primary gastrointestinal diffuse large B-cell lymphoma treated with CHOP-like regimen and rituximab

The aims of the present study were to elucidate the transcript levels of DNA methyltransferase (DNMT)1, DNMT3a and DNMT3b by quantitative polymerase chain reaction in patients with primary gastrointestinal diffuse large B-cell lymphoma (PGI-DLBCL), and determine the association of their expression w...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Oncology letters 2015-05, Vol.9 (5), p.2307-2312
Hauptverfasser:	ZHAO, HAIFENG, ZHANG, LE, GUO, SHANQI, YUAN, TIAN, XIA, BING, ZHANG, LIANYU, ZHANG, YIZHUO
Format:	Artikel
Sprache:	eng
Schlagworte:	Antimitotic agents Antineoplastic agents Development and progression diffuse large B-cell lymphoma DNA methyltransferase 1 Dosage and administration Drug therapy Drug therapy, Combination Gastrointestinal cancer gastrointestinal lymphoma Gene expression Genetic aspects Health aspects Lymphomas Methods Methyltransferases Patient outcomes prognosis
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The aims of the present study were to elucidate the transcript levels of DNA methyltransferase (DNMT)1, DNMT3a and DNMT3b by quantitative polymerase chain reaction in patients with primary gastrointestinal diffuse large B-cell lymphoma (PGI-DLBCL), and determine the association of their expression with the clinical parameters and prognostic values of the disease. The results revealed that the expression of DNMT1 in patients with PGI-DLBCL was significantly higher than that in healthy controls (P=0.04), while the expression of DNMT3a and DNMT3b were significantly lower (P
ISSN:	1792-1074 1792-1082
DOI:	10.3892/ol.2015.3038