Toll-like receptor genetic variants are associated with Gram-negative infections in VLBW infants

Objective: To test the hypothesis that single-nucleotide polymorphisms (SNPs) in Toll-like receptor (TLR) genes alter susceptibility to bacterial infections and modulate white blood cell (WBC) counts during infections in very low birth weight (VLBW) infants (birth weight

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of perinatology 2013-10, Vol.33 (10), p.772-777
Hauptverfasser:	Sampath, V, Mulrooney, N P, Garland, J S, He, J, Patel, A L, Cohen, J D, Simpson, P M, Hines, R N
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/726/649 631/250/262/2106/2108 692/699/255/1318 692/700/1720 African Americans - genetics Bacteria Bacterial diseases Bacterial infections Birth weight Blood European Continental Ancestry Group - genetics Female Genetic aspects Genetic diversity Genetic Predisposition to Disease - genetics Genetic variance Genetic Variation Gram-negative bacterial infections Gram-Negative Bacterial Infections - blood Gram-Negative Bacterial Infections - genetics Health aspects Health risks Hospitals Humans Immune response Immune system Immunity, Innate - genetics Infant, Newborn Infant, Premature Infant, Premature, Diseases - genetics Infant, Very Low Birth Weight - physiology Infants Infections Intensive care Interleukin-1 Receptor-Associated Kinases - genetics IRAK protein Leukocyte Count Leukocytes Logistic Models Low birth weight Male Medicine Medicine & Public Health Neutrophils Nucleotides original-article Pathogens Pediatric Surgery Pediatrics Polymorphism, Single Nucleotide - genetics Receptors Regression analysis Regression models Risk Factors Sepsis Single nucleotide polymorphisms Single-nucleotide polymorphism TLR4 protein TLR5 protein Toll-Like Receptor 4 - genetics Toll-Like Receptor 5 - genetics Toll-like receptors Toll-Like Receptors - genetics
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Beschreibung
Zusammenfassung:	Objective: To test the hypothesis that single-nucleotide polymorphisms (SNPs) in Toll-like receptor (TLR) genes alter susceptibility to bacterial infections and modulate white blood cell (WBC) counts during infections in very low birth weight (VLBW) infants (birth weight
ISSN:	0743-8346 1476-5543
DOI:	10.1038/jp.2013.80