Telomere length and telomerase in a well-characterized sample of individuals with major depressive disorder compared to controls

Telomere length and telomerase in a well-characterized sample of individuals with major depressive disorder compared to controls

Highlights • Leukocyte telomere length (LTL) was not associated with depression. • Telomerase activity was higher in men with depression even after adjustment for potential confounders. • Variability in reports of LTL in depression might be due to residual confounding and methodology differences....

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Veröffentlicht in:Psychoneuroendocrinology 2015-08, Vol.58, p.9-22
Hauptverfasser: Simon, Naomi M, Walton, Zandra E, Bui, Eric, Prescott, Jennifer, Hoge, Elizabeth, Keshaviah, Aparna, Schwarz, Noah, Dryman, Taylor, Ojserkis, Rebecca A, Kovachy, Benjamin, Mischoulon, David, Worthington, John, DeVivo, Immaculata, Fava, Maurizio, Wong, Kwok-Kin
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Adult
Aged
Depressive Disorder, Major - genetics
Depressive Disorder, Major - metabolism
Endocrinology & Metabolism
Female
Humans
Major depressive disorder
Male
Middle Aged
Psychiatry
Telomerase
Telomerase - blood
Telomere - genetics
Telomere - metabolism
Telomere Homeostasis
Telomere length
Young Adult
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Zusammenfassung:Highlights • Leukocyte telomere length (LTL) was not associated with depression. • Telomerase activity was higher in men with depression even after adjustment for potential confounders. • Variability in reports of LTL in depression might be due to residual confounding and methodology differences.
ISSN:0306-4530
1873-3360
DOI:10.1016/j.psyneuen.2015.04.004