Temporal regularity determines the impact of electrical stimulation on tactile reactivity and response to capsaicin in spinally transected rats

Highlights ► Spinal neurons are sensitive to temporal relationships. ► Exposure to irregular stimulation enhances tactile reactivity. ► Exposure to regular stimulation diminishes tactile reactivity. ► Exposure to regular stimulation prevents and reverses capsaicin-induced sensitivity.

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Bibliographische Detailangaben
Veröffentlicht in:	Neuroscience 2012-12, Vol.227, p.119-133
Hauptverfasser:	Baumbauer, K.M, Lee, K.H, Puga, D.A, Woller, S.A, Hughes, A.J, Grau, J.W
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals Biological and medical sciences capsaicin Capsaicin - pharmacology Disease Models, Animal Electric Stimulation - methods Electroshock - adverse effects Fundamental and applied biological sciences. Psychology Hyperalgesia - physiopathology learning Male Neurology pain Pain Measurement Pain Threshold - drug effects plasticity Rats Rats, Sprague-Dawley Sensory System Agents - pharmacology Somesthesis and somesthetic pathways (proprioception, exteroception, nociception) interoception electrolocation. Sensory receptors Spinal Cord Injuries - physiopathology spinal cord injury Time Factors Touch - drug effects Touch - physiology Vertebrates: nervous system and sense organs
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Beschreibung
Zusammenfassung:	Highlights ► Spinal neurons are sensitive to temporal relationships. ► Exposure to irregular stimulation enhances tactile reactivity. ► Exposure to regular stimulation diminishes tactile reactivity. ► Exposure to regular stimulation prevents and reverses capsaicin-induced sensitivity.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2012.09.054