The impact of plasma epstein–barr virus DNA and fibrinogen on nasopharyngeal carcinoma prognosis: an observational study

Background: The impact of combining plasma fibrinogen levels with Epstein–Barr Virus DNA (EBV DNA) levels on the prognosis for patients with nasopharyngeal carcinoma (NPC) was evaluated. Methods: In this observational study, 2563 patients with non-metastatic NPC were evaluated for the effects of cir...

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Veröffentlicht in:	British journal of cancer 2014-09, Vol.111 (6), p.1102-1111
Hauptverfasser:	Tang, L-Q, Chen, Q-Y, Guo, S-S, Chen, W-H, Li, C-F, Zhang, L, Lai, X-P, He, Y, Xu, Y-X-X, Hu, D-P, Wen, S-H, Peng, Y-T, Liu, H, Liu, L-T, Yan, S-M, Guo, L, Zhao, C, Cao, K-J, Liu, Q, Qian, C-N, Ma, J, Guo, X, Zeng, M-S, Mai, H-Q
Format:	Artikel
Sprache:	eng
Schlagworte:	692/53 692/699/67/1536 692/700/1750 Adult Biological and medical sciences Biomarkers Biomarkers, Tumor - blood Biomedical and Life Sciences Biomedicine Cancer Research Cancer therapies Carcinoma - blood Carcinoma - pathology Carcinoma - virology Chemotherapy Clinical Study Disease-Free Survival DNA, Viral - blood Drug Resistance Epidemiology Epstein-Barr virus Female Fibrinogen - metabolism Follow-Up Studies Herpesvirus 4, Human - genetics Humans Infectious diseases Kaplan-Meier Estimate Male Medical prognosis Medical sciences Metastasis Middle Aged Molecular Medicine Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Nasopharyngeal Neoplasms - blood Nasopharyngeal Neoplasms - pathology Nasopharyngeal Neoplasms - virology Neoplasm Recurrence, Local - blood Neoplasm Recurrence, Local - virology Neoplasm Staging Observational studies Oncology Patients Plasma Radiation therapy Survival Rate Tumors Viral diseases
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Zusammenfassung:	Background: The impact of combining plasma fibrinogen levels with Epstein–Barr Virus DNA (EBV DNA) levels on the prognosis for patients with nasopharyngeal carcinoma (NPC) was evaluated. Methods: In this observational study, 2563 patients with non-metastatic NPC were evaluated for the effects of circulating plasma fibrinogen and EBV DNA levels on disease-free survival (DFS), distant metastasis-free survival (DMFS), and overall survival (OS). Results: Compared with the bottom biomarker tertiles, TNM stage-adjusted hazard ratios (HR, 95% confidence intervals (CIs)) for predicting DFS in fibrinogen tertiles 2 to 3 were 1.26 (1.00 to 1.60) and 1.81 (1.45 to 2.26), respectively; HR for EBV DNA tertiles 2 to 3 were 1.49 (1.12 to 1.98) and 4.24 (3.27 to 5.49), respectively. After additional adjustment for established risk factors, both biomarkers were still associated ( P for trend
ISSN:	0007-0920 1532-1827
DOI:	10.1038/bjc.2014.393