Key role of dual specificity kinase TTK in proliferation and survival of pancreatic cancer cells

Background: Pancreatic ductal adenocarcinoma (PDAC) is among the most aggressive human malignancies with an overall 5-year survival rate of

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Bibliographische Detailangaben
Veröffentlicht in:	British journal of cancer 2014-10, Vol.111 (9), p.1780-1787
Hauptverfasser:	Kaistha, B P, Honstein, T, Müller, V, Bielak, S, Sauer, M, Kreider, R, Fassan, M, Scarpa, A, Schmees, C, Volkmer, H, Gress, T M, Buchholz, M
Format:	Artikel
Sprache:	eng
Schlagworte:	631/136/2091 631/67/1059/602 631/67/1504/1713 Adenocarcinoma - metabolism Adenocarcinoma - pathology Apoptosis Biological and medical sciences Biomarkers, Tumor - metabolism Biomedical and Life Sciences Biomedicine Blotting, Western Cancer Research Carcinoma, Pancreatic Ductal - metabolism Carcinoma, Pancreatic Ductal - pathology Case-Control Studies Cell Cycle Proteins - metabolism Cell Proliferation Drug Resistance Epidemiology Gastroenterology. Liver. Pancreas. Abdomen Humans Immunoenzyme Techniques Liver. Biliary tract. Portal circulation. Exocrine pancreas Medical sciences Molecular Diagnostics Molecular Medicine Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Oncology Pancreas - metabolism Pancreatic cancer Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Protein-Serine-Threonine Kinases - metabolism Protein-Tyrosine Kinases - metabolism Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics Tissue Array Analysis Tumor Cells, Cultured Tumors
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Beschreibung
Zusammenfassung:	Background: Pancreatic ductal adenocarcinoma (PDAC) is among the most aggressive human malignancies with an overall 5-year survival rate of
ISSN:	0007-0920 1532-1827
DOI:	10.1038/bjc.2014.460