Age-dependent variation in cytokines, chemokines and biologic analytes rinsed from the surface of healthy human skin

In the skin, aging is associated with overall epidermal thinning, decreased barrier function and gradual deterioration of the epidermal immune response. However, the presence and role of cytokines, chemokines and biologic analytes (CCBAs) in immunosenescence are not known. Here we identified age-related changes in skin properties and CCBAs from stratum corneum of healthy human subjects, providing a means to utilize CCBAs as benchmarks for aging skin health. Transepidermal water loss and a(*) (skin redness) decreased in an age-dependent manner and were significantly lower (p