Effect of Statins on Skeletal Muscle Function

Many clinicians believe that statins cause muscle pain, but this has not been observed in clinical trials, and the effect of statins on muscle performance has not been carefully studied. The Effect of Statins on Skeletal Muscle Function and Performance (STOMP) study assessed symptoms and measured cr...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2013-01, Vol.127 (1), p.96-103
Hauptverfasser:	PARKER, Beth A, CAPIZZI, Jeffrey A, THOMPSON, Paul D, GRIMALDI, Adam S, CLARKSON, Priscilla M, COLE, Stephanie M, KEADLE, Justin, CHIPKIN, Stuart, PESCATELLO, Linda S, SIMPSON, Kathleen, MICHAEL WHITE, C
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antihypertensive agents Atorvastatin Calcium Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cardiovascular system Creatine Kinase - blood Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Double-Blind Method Exercise Test Exercise Tolerance - drug effects Female Heptanoic Acids - administration & dosage Heptanoic Acids - adverse effects Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects Male Medical sciences Middle Aged Muscle Strength - drug effects Muscle, Skeletal - drug effects Musculoskeletal Pain - chemically induced Pharmacology. Drug treatments Placebos Pyrroles - administration & dosage Pyrroles - adverse effects Young Adult
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Many clinicians believe that statins cause muscle pain, but this has not been observed in clinical trials, and the effect of statins on muscle performance has not been carefully studied. The Effect of Statins on Skeletal Muscle Function and Performance (STOMP) study assessed symptoms and measured creatine kinase, exercise capacity, and muscle strength before and after atorvastatin 80 mg or placebo was administered for 6 months to 420 healthy, statin-naive subjects. No individual creatine kinase value exceeded 10 times normal, but average creatine kinase increased 20.8±141.1 U/L (P
ISSN:	0009-7322 1524-4539
DOI:	10.1161/circulationaha.112.136101