Connexin 43 deficiency accelerates skin wound healing and extracellular matrix remodeling in mice

Connexin 43 deficiency accelerates skin wound healing and extracellular matrix remodeling in mice

Highlights • Cx43 deficiency accelerates re-epithelialization and wound closure. • Cx43 deficiency increases proliferation and activation of dermal fibroblasts. • Cx43 deficiency enhances the expression of extracellular matrix remodeling factors. • Cx43 may contribute to the development of new thera...

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Veröffentlicht in:Journal of dermatological science 2015-07, Vol.79 (1), p.50-56
Hauptverfasser: Cogliati, Bruno, Vinken, Mathieu, Silva, Tereza C, Araújo, Cintia M.M, Aloia, Thiago P.A, Chaible, Lucas M, Mori, Cláudia M.C, Dagli, Maria L.Z
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Cell Proliferation
Collagen - metabolism
Connexin 43
Connexin 43 - deficiency
Connexin 43 - genetics
Dermatology
Extracellular Matrix - metabolism
Fibroblasts - physiology
Gap junction
Heterozygote
Male
Mice
Mice, Knockout
Neovascularization, Physiologic
Re-Epithelialization - physiology
Skin repair
Wound healing
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Zusammenfassung:Highlights • Cx43 deficiency accelerates re-epithelialization and wound closure. • Cx43 deficiency increases proliferation and activation of dermal fibroblasts. • Cx43 deficiency enhances the expression of extracellular matrix remodeling factors. • Cx43 may contribute to the development of new therapeutic target in wound healing.
ISSN:0923-1811
1873-569X
DOI:10.1016/j.jdermsci.2015.03.019