Tet3 regulates synaptic transmission and homeostatic plasticity via DNA oxidation and repair

The cellular function of active DNA demethylation in neurons is not well understood. Here, Song and colleagues show that synaptic activity modulates Tet3 signaling, which in turn regulates glutamatergic synaptic transmission and synaptic scaling. Their work identifies Tet3 as a synaptic activity sen...

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Veröffentlicht in:	Nature neuroscience 2015-06, Vol.18 (6), p.836-843
Hauptverfasser:	Yu, Huimei, Su, Yijing, Shin, Jaehoon, Zhong, Chun, Guo, Junjie U, Weng, Yi-Lan, Gao, Fuying, Geschwind, Daniel H, Coppola, Giovanni, Ming, Guo-li, Song, Hongjun
Format:	Artikel
Sprache:	eng
Schlagworte:	13 38 38/23 45 631/378/2584/1695 631/378/2591 631/378/87 Analysis Animal Genetics and Genomics Animals Behavioral Sciences Biological Techniques Biomedicine DNA - metabolism DNA Methylation DNA repair DNA Repair - physiology DNA-Binding Proteins - genetics DNA-Binding Proteins - physiology Gene expression Gene Knockdown Techniques Genetic aspects Genomes Homeostasis - physiology In Vitro Techniques Medicine Mice Mice, Inbred C57BL Neural transmission Neurobiology Neuronal Plasticity - genetics Neuronal Plasticity - physiology Neurosciences Oxidation Oxidation-Reduction Physiological aspects Proteins Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - physiology Receptors, AMPA - metabolism Signal Transduction - genetics Signal Transduction - physiology Synaptic Transmission - physiology
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