Plasma matrix metalloproteinase 2 levels and breast cancer risk

Highlights • Pre-diagnostic plasma MMP2 was unassociated with total invasive breast cancer risk. • MMP2 was associated with an increased risk of nodal metastases at diagnosis. • No associations were observed with other tumor features or recurrent/fatal cancers. • MMP2 warrants further study as an ea...

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Veröffentlicht in:	Cancer epidemiology 2015-06, Vol.39 (3), p.321-327
Hauptverfasser:	Aroner, Sarah A, Rosner, Bernard A, Tamimi, Rulla M, Tworoger, Shelley S, Baur, Nadja, Joos, Thomas O, Hankinson, Susan E
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers Breast cancer Breast Neoplasms - blood Breast Neoplasms - enzymology Breast Neoplasms - pathology Cancer Case-Control Studies Confidence intervals Epidemiology Female Hematology, Oncology and Palliative Medicine Humans Internal Medicine Laboratories Logistic Models Lymphatic system Male Matrix Metalloproteinase 2 - blood Matrix metalloproteinases Metastasis Middle Aged Nested case–control Nurses Odds Ratio Plasma Prospective Studies Risk Risk Factors Studies Tumors Womens health
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Beschreibung
Zusammenfassung:	Highlights • Pre-diagnostic plasma MMP2 was unassociated with total invasive breast cancer risk. • MMP2 was associated with an increased risk of nodal metastases at diagnosis. • No associations were observed with other tumor features or recurrent/fatal cancers. • MMP2 warrants further study as an early indicator of aggressive breast cancer risk.
ISSN:	1877-7821 1877-783X
DOI:	10.1016/j.canep.2015.02.010