Proton spectroscopic imaging of brain metabolites in basal ganglia of healthy older adults

Object We sought to measure brain metabolite levels in healthy older people. Materials and methods Spectroscopic imaging at the level of the basal ganglia was applied in 40 participants aged 73–74 years. Levels of the metabolites N -acetyl aspartate (NAA), choline, and creatine were determined in &q...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Magma (New York, N.Y.) N.Y.), 2015-06, Vol.28 (3), p.251-257
Hauptverfasser:	Parikh, Jehill, Thrippleton, Michael J., Murray, Catherine, Armitage, Paul A., Harris, Bridget A., Andrews, Peter J. D., Wardlaw, Joanna M., Starr, John M., Deary, Ian J., Marshall, Ian
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aspartic Acid - analogs & derivatives Aspartic Acid - metabolism Basal Ganglia - anatomy & histology Basal Ganglia - metabolism Biomedical Engineering and Bioengineering Choline - metabolism Computer Appl. in Life Sciences Creatine - metabolism Female Health Informatics Humans Image Interpretation, Computer-Assisted - methods Imaging Magnetic Resonance Imaging - methods Male Medicine Medicine & Public Health Molecular Imaging - methods Proton Magnetic Resonance Spectroscopy - methods Radiology Reproducibility of Results Research Article Sensitivity and Specificity Solid State Physics Tissue Distribution
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Object We sought to measure brain metabolite levels in healthy older people. Materials and methods Spectroscopic imaging at the level of the basal ganglia was applied in 40 participants aged 73–74 years. Levels of the metabolites N -acetyl aspartate (NAA), choline, and creatine were determined in "institutional units" (IU) corrected for T1 and T2 relaxation effects. Structural imaging enabled determination of grey matter (GM), white matter (WM), and cerebrospinal fluid content. ANOVA analysis was carried out for voxels satisfying quality criteria. Results Creatine levels were greater in GM than WM (57 vs. 44 IU, p
ISSN:	0968-5243 1352-8661
DOI:	10.1007/s10334-014-0465-0