Determinants of immunodominance for CD4 T cells

Highlights • Immunodominant epitope processing and selection requires DM, MHC II, and cathepsins. • Immunodominance is determined by epitope abundance. • Antigens from different source might be processed differently. • Pathogen derived epitopes are captured on intact antigens and are insensitive to...

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Veröffentlicht in:Current opinion in immunology 2015-06, Vol.34, p.9-15
Hauptverfasser: Kim, AeRyon, Sadegh-Nasseri, Scheherazade
Format: Artikel
Sprache:eng
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Zusammenfassung:Highlights • Immunodominant epitope processing and selection requires DM, MHC II, and cathepsins. • Immunodominance is determined by epitope abundance. • Antigens from different source might be processed differently. • Pathogen derived epitopes are captured on intact antigens and are insensitive to DM. • Autoantigens are captured as peptides and are insensitive to cathepsins.
ISSN:0952-7915
1879-0372
DOI:10.1016/j.coi.2014.12.005