Determinants of immunodominance for CD4 T cells
Highlights • Immunodominant epitope processing and selection requires DM, MHC II, and cathepsins. • Immunodominance is determined by epitope abundance. • Antigens from different source might be processed differently. • Pathogen derived epitopes are captured on intact antigens and are insensitive to...
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Veröffentlicht in: | Current opinion in immunology 2015-06, Vol.34, p.9-15 |
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Hauptverfasser: | , |
Format: | Artikel |
Sprache: | eng |
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Online-Zugang: | Volltext |
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Zusammenfassung: | Highlights • Immunodominant epitope processing and selection requires DM, MHC II, and cathepsins. • Immunodominance is determined by epitope abundance. • Antigens from different source might be processed differently. • Pathogen derived epitopes are captured on intact antigens and are insensitive to DM. • Autoantigens are captured as peptides and are insensitive to cathepsins. |
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ISSN: | 0952-7915 1879-0372 |
DOI: | 10.1016/j.coi.2014.12.005 |