Effect of transforming growth factor-β1 869C/T polymorphism and radiation pneumonitis

The Transforming growth factor-β1 (TGFβ1) 869C/T polymorphism was associated with radiation pneumonitis (RP) susceptibility. However, the results remained controversial. Thus, a meta-analysis was conducted. Relevant studies were systematically searched by using the NCBI, Medline, Web of Science and...

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Veröffentlicht in:	International journal of clinical and experimental pathology 2015, Vol.8 (3), p.2835-2839
Hauptverfasser:	Wang, Yingtian, Wang, Xingguang, Wang, Xiyan, Zhang, Deyong, Jiang, Shujuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Genetic Predisposition to Disease Humans Odds Ratio Original Phenotype Polymorphism, Genetic Radiation Pneumonitis - diagnosis Radiation Pneumonitis - genetics Risk Assessment Risk Factors Transforming Growth Factor beta1 - genetics
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Zusammenfassung:	The Transforming growth factor-β1 (TGFβ1) 869C/T polymorphism was associated with radiation pneumonitis (RP) susceptibility. However, the results remained controversial. Thus, a meta-analysis was conducted. Relevant studies were systematically searched by using the NCBI, Medline, Web of Science and Embase databases. Summary odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimated using random-effects models. There was a significant association between TGFβ1 869C/T polymorphism and RP susceptibility (OR=1.77; 95% CI, 1.27-2.47; P=0.0007). This study suggested that TGFβ1 869C/T polymorphism was a risk factor of RP.
ISSN:	1936-2625