Impact of hippocampal neuronal ablation on neurogenesis and cognition in the aged brain

Highlights • Aged lesioned CaM/Tet-DTA mice exhibit significant hippocampal neuronal loss. • Neurogenesis is upregulated in aged CaM/Tet-DTA mice. • Neurogenesis is insufficient to mitigate cognitive deficits in aged CaM/Tet-DTA mice.

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Bibliographische Detailangaben
Veröffentlicht in:	Neuroscience 2014-02, Vol.259, p.214-222
Hauptverfasser:	Yeung, S.T, Myczek, K, Kang, A.P, Chabrier, M.A, Baglietto-Vargas, D, LaFerla, F.M
Format:	Artikel
Sprache:	eng
Schlagworte:	Ablation Techniques Aging Animals Astrocytes - metabolism Biological and medical sciences Calcium-Calmodulin-Dependent Protein Kinase Type 1 - genetics Cell Count Cognition Disorders - etiology Diphtheria Toxin - genetics Disks Large Homolog 4 Protein Doublecortin Protein Fundamental and applied biological sciences. Psychology Gene Expression Regulation - physiology Guanylate Kinases - metabolism hippocampus Hippocampus - injuries Hippocampus - pathology Maze Learning - physiology Membrane Proteins - metabolism Mice Mice, Transgenic neurodegenerative disorders neurogenesis Neurogenesis - physiology Neurology neuronal loss Neurons - physiology Peptide Fragments - genetics Phosphopyruvate Hydratase - metabolism S100 Calcium Binding Protein beta Subunit - metabolism Synaptophysin - metabolism Vertebrates: nervous system and sense organs
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Beschreibung
Zusammenfassung:	Highlights • Aged lesioned CaM/Tet-DTA mice exhibit significant hippocampal neuronal loss. • Neurogenesis is upregulated in aged CaM/Tet-DTA mice. • Neurogenesis is insufficient to mitigate cognitive deficits in aged CaM/Tet-DTA mice.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2013.11.054