Preemptive dosage reduction of nadroparin in patients with renal failure: a retrospective case series

BackgroundLow-molecular-weight heparins (LMWHs) are frequently used to treat arterial and venous thrombo-embolic events. LMWHs accumulate with renal failure, but only limited clinical data regarding appropriate dosage adjustments are available. Nevertheless, LMWHs are routinely used in these patient...

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Veröffentlicht in:	Clinical kidney journal 2013-10, Vol.6 (5), p.473-477
Hauptverfasser:	Russcher, Marije, Josephus Jitta, Nienke, Kraaijenhagen, Rob J., Fijnheer, Rob, Pasker-de Jong, Pieternel C. M., Gaillard, Carlo A. J. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Original Contributions
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Zusammenfassung:	BackgroundLow-molecular-weight heparins (LMWHs) are frequently used to treat arterial and venous thrombo-embolic events. LMWHs accumulate with renal failure, but only limited clinical data regarding appropriate dosage adjustments are available. Nevertheless, LMWHs are routinely used in these patients worldwide. Although many clinics apply renal function-based dosage reductions, anti-factor Xa (anti-Xa) activity is not measured routinely.MethodsWe determined anti-Xa activity in 51 patients with MDRD-eGFR
ISSN:	2048-8505 2048-8513
DOI:	10.1093/ckj/sft083