Comparison of the Vidas C. difficile GDH Automated Enzyme-Linked Fluorescence Immunoassay (ELFA) with Another Commercial Enzyme Immunoassay (EIA) (Quik Chek-60), Two Selective Media, and a PCR Assay for gluD for Detection of Clostridium difficile in Fecal Samples

Prevention and management of Clostridium difficile infection (CDI) can be improved by rapid and reliable diagnostics. The Vidas C. difficile glutamate dehydrogenase assay had performance comparable to that of the Quik Chek-60 assay (overall agreement, 95%) and a sensitivity of >93%; thus, it is s...

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Veröffentlicht in:	Journal of clinical microbiology 2015-06, Vol.53 (6), p.1931-1934
Hauptverfasser:	Davies, K A, Berry, C E, Morris, K A, Smith, R, Young, S, Davis, T E, Fuller, D D, Buckner, R J, Wilcox, M H
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult ATP-Binding Cassette Transporters - genetics Bacterial Proteins - genetics Bacterial Typing Techniques - methods Bacteriology Child Child, Preschool Clostridium difficile Clostridium difficile - genetics Clostridium difficile - isolation & purification Culture Media Enterocolitis, Pseudomembranous - diagnosis Enterocolitis, Pseudomembranous - microbiology Enzyme-Linked Immunosorbent Assay - methods Feces - microbiology Humans Infant Infant, Newborn Male Middle Aged Polymerase Chain Reaction - methods Prospective Studies Reproducibility of Results Sensitivity and Specificity Young Adult
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Zusammenfassung:	Prevention and management of Clostridium difficile infection (CDI) can be improved by rapid and reliable diagnostics. The Vidas C. difficile glutamate dehydrogenase assay had performance comparable to that of the Quik Chek-60 assay (overall agreement, 95%) and a sensitivity of >93%; thus, it is suitable as the first test in two-stage algorithms for a CDI diagnosis.
ISSN:	0095-1137 1098-660X
DOI:	10.1128/JCM.00649-15