Combat-Related Pythium aphanidermatum Invasive Wound Infection: Case Report and Discussion of Utility of Molecular Diagnostics

Combat-Related Pythium aphanidermatum Invasive Wound Infection: Case Report and Discussion of Utility of Molecular Diagnostics

We describe a 22-year-old soldier with 19% total body surface area burns, polytrauma, and sequence- and culture-confirmed Pythium aphanidermatum wound infection. Antemortem histopathology suggested disseminated Pythium infection, including brain involvement; however, postmortem PCR revealed Cunningh...

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Veröffentlicht in:Journal of clinical microbiology 2015-06, Vol.53 (6), p.1968-1975
Hauptverfasser: Farmer, Aaron R, Murray, Clinton K, Driscoll, Ian R, Wickes, Brian L, Wiederhold, Nathan, Sutton, Deanna A, Sanders, Carmita, Mende, Katrin, Enniss, Brent, Feig, James, Ganesan, Anuradha, Rini, Elizabeth A, Vento, Todd J
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Blast Injuries
Bombs
Case Reports
Fatal Outcome
Humans
Male
Military Personnel
Molecular Diagnostic Techniques
Pythiosis
Pythium - genetics
Pythium - isolation & purification
Wound Infection
Young Adult
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Zusammenfassung:We describe a 22-year-old soldier with 19% total body surface area burns, polytrauma, and sequence- and culture-confirmed Pythium aphanidermatum wound infection. Antemortem histopathology suggested disseminated Pythium infection, including brain involvement; however, postmortem PCR revealed Cunninghamella elegans, Lichtheimia corymbifera, and Saksenaea vasiformis coinfection. The utility of molecular diagnostics in invasive fungal infections is discussed.
ISSN:0095-1137
1098-660X
DOI:10.1128/JCM.00410-15