Evaluation of [11C]CB184 for imaging and quantification of TSPO overexpression in a rat model of herpes encephalitis
Purpose Evaluation of translocator protein (TSPO) overexpression is considered an attractive research tool for monitoring neuroinflammation in several neurological and psychiatric disorders. [ 11 C]PK11195 PET imaging has been widely used for this purpose. However, it has a low sensitivity and a poo...
Gespeichert in:
Veröffentlicht in: | European journal of nuclear medicine and molecular imaging 2015-06, Vol.42 (7), p.1106-1118 |
---|---|
Hauptverfasser: | , , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
Zusammenfassung: | Purpose
Evaluation of translocator protein (TSPO) overexpression is considered an attractive research tool for monitoring neuroinflammation in several neurological and psychiatric disorders. [
11
C]PK11195 PET imaging has been widely used for this purpose. However, it has a low sensitivity and a poor signal-to-noise ratio. For these reasons, [
11
C]CB184 was evaluated as a potentially more sensitive PET tracer.
Methods
A model of herpes simplex encephalitis (HSE) was induced in male Wistar rats. On day 6 or 7 after virus inoculation, [
11
C]CB184 PET scans were acquired followed by ex vivo evaluation of biodistribution. In addition, [
11
C]CB184 and [
11
C]PK11195 PET scans with arterial blood sampling were acquired to generate input for pharmacokinetic modelling. Differences between the saline-treated control group and the virus-treated HSE group were explored using volumes of interest and voxel-based analysis.
Results
The biodistribution study showed significantly higher [
11
C]CB184 uptake in the amygdala, olfactory bulb, medulla, pons and striatum (
p
|
---|---|
ISSN: | 1619-7070 1619-7089 |
DOI: | 10.1007/s00259-015-3021-x |