Meter-Long Multiblock Copolymer Microfibers Via Interfacial Bioorthogonal Polymerization

Meter-Long Multiblock Copolymer Microfibers Via Interfacial Bioorthogonal Polymerization

High‐molecular‐weight multiblock copolymers are synthesized as robust polymer fibers via interfacial bioorthogonal polymerization employing the rapid cycloaddition of s‐tetrazines with strained trans‐cyclooctenes. When cell‐adhesive peptide is incorporated in the tetrazine monomer, the resulting pro...

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Veröffentlicht in:Advanced materials (Weinheim) 2015-05, Vol.27 (17), p.2783-2790
Hauptverfasser: Liu, Shuang, Zhang, Han, Remy, Roddel A., Deng, Fei, Mackay, Michael E., Fox, Joseph M., Jia, Xinqiao
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Attachment
Biomimetic Materials - chemistry
bioorthogonal
Calorimetry, Differential Scanning
Copolymers
Cycloaddition
Cycloaddition Reaction
Cyclooctanes - chemistry
Elongation
Fibers
guidance cues
Heterocyclic Compounds, 1-Ring - chemistry
interfacial polymerization
Mice
Microfibers
Microscopy, Atomic Force
Microscopy, Confocal
Monomers
multiblock copolymer
NIH 3T3 Cells
Polymerization
Polymers - chemistry
Temperature
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Zusammenfassung:High‐molecular‐weight multiblock copolymers are synthesized as robust polymer fibers via interfacial bioorthogonal polymerization employing the rapid cycloaddition of s‐tetrazines with strained trans‐cyclooctenes. When cell‐adhesive peptide is incorporated in the tetrazine monomer, the resulting protein‐mimetic polymer fibers provide guidance cues for cell attachment and elongation.
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.201500360