Chemokine decoy receptor D6 in inflammatory bowel disease (IBD) and IBD-associated colon cancer

Lacking a cytoplasmic domain, it binds IL-1Î², without triggering signal transduction. [...]the receptor was defined as "structurally incapable of transducing signal but able to recognise the agonist with high affinity and specificity" 1 acting as a "sink" to prevent ligand activ...

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Veröffentlicht in:	Gut 2010-02, Vol.59 (2), p.151-152
Hauptverfasser:	Collins, Colm B, McNamee, Eoin N, Wermers, Joshua D, Lebsack, Matthew D P, Rivera-Nieves, Jesús
Format:	Artikel
Sprache:	eng
Schlagworte:	Cancer immunobiology Chemokine Receptor D6 Chemokines Colonic Neoplasms - etiology Colonic Neoplasms - metabolism Dendritic cells experimental colitis Humans Hypotheses Inflammation Inflammatory bowel disease Inflammatory Bowel Diseases - complications Inflammatory Bowel Diseases - metabolism Leukocytes - metabolism Ligands Receptors, CCR10 - metabolism Rodents Signal transduction
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Beschreibung
Zusammenfassung:	Lacking a cytoplasmic domain, it binds IL-1Î², without triggering signal transduction. [...]the receptor was defined as "structurally incapable of transducing signal but able to recognise the agonist with high affinity and specificity" 1 acting as a "sink" to prevent ligand activity. [...]a challenge in modulating the immune response is immunosuppression, leading to opportunistic infections.
ISSN:	0017-5749 1468-3288
DOI:	10.1136/gut.2009.192708