Are mutagenic non D-loop direct repeat motifs in mitochondrial DNA under a negative selection pressure?

Non D-loop direct repeats (DRs) in mitochondrial DNA (mtDNA) have been commonly implicated in the mutagenesis of mtDNA deletions associated with neuromuscular disease and ageing. Further, these DRs have been hypothesized to put a constraint on the lifespan of mammals and are under a negative selecti...

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Veröffentlicht in:Nucleic acids research 2015-04, Vol.43 (8), p.4098-4108
Hauptverfasser: Lakshmanan, Lakshmi Narayanan, Gruber, Jan, Halliwell, Barry, Gunawan, Rudiyanto
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Sprache:eng
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