Emergent and evolving antimicrobial resistance cassettes in community-associated fusidic acid and meticillin-resistant Staphylococcus aureus

Highlights • Resistance to fusidic acid rose among meticillin-resistant Staphylococcus aureus (MRSA) during the 2000s. • Combined surveillance data and whole-genome sequencing analysis dissected changes in the epidemiology of MRSA. • Fusidic acid resistance emerged fastest in the community, where it...

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Veröffentlicht in:	International journal of antimicrobial agents 2015-05, Vol.45 (5), p.477-484
Hauptverfasser:	Ellington, Matthew J, Reuter, Sandra, Harris, Simon R, Holden, Matthew T.G, Cartwright, Edward J, Greaves, Daniel, Gerver, Sarah M, Hope, Russell, Brown, Nicholas M, Török, M. Estee, Parkhill, Julian, Köser, Claudio U, Peacock, Sharon J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use Antimicrobial resistance CA-MRSA Child, Preschool Community-Acquired Infections - epidemiology Community-Acquired Infections - microbiology Drug Resistance, Bacterial Drug Utilization - trends Evolution, Molecular Female Fusidic Acid - pharmacology Fusidic Acid - therapeutic use Genes, Bacterial Humans Infectious Disease Male Methicillin-Resistant Staphylococcus aureus - drug effects Methicillin-Resistant Staphylococcus aureus - genetics Methicillin-Resistant Staphylococcus aureus - isolation & purification Middle Aged Prevalence SCC genomics Staphylococcal Infections - epidemiology Staphylococcal Infections - microbiology Staphylococcus aureus Surveillance United Kingdom - epidemiology Young Adult
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Beschreibung
Zusammenfassung:	Highlights • Resistance to fusidic acid rose among meticillin-resistant Staphylococcus aureus (MRSA) during the 2000s. • Combined surveillance data and whole-genome sequencing analysis dissected changes in the epidemiology of MRSA. • Fusidic acid resistance emerged fastest in the community, where it was used the most. • Resistance occurred in diverse MRSA strains, encoded on staphylococcal cassette chromosome (SCC) elements. • Compact chimeric dual-resistance cassettes indicate a new mechanism for resistance accrual in MRSA.
ISSN:	0924-8579 1872-7913
DOI:	10.1016/j.ijantimicag.2015.01.009