Primary immunoglobulin repertoire development: time and space matter

Highlights • V(D)J recombination drives the generation of the primary immunoglobulin repertoire. • Selection forces define limits to emerging immunoglobulin diversity. • Naïve Ig repertoires are shaped by antigen encounter during B cell development. • Timing and location of early B cell development...

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Veröffentlicht in:	Current opinion in immunology 2015-04, Vol.33, p.126-131
Hauptverfasser:	Granato, Alessandra, Chen, Yuezhou, Wesemann, Duane R
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Antigens - immunology B-Lymphocytes - cytology B-Lymphocytes - immunology B-Lymphocytes - metabolism Cell Differentiation Clonal Selection, Antigen-Mediated Gene Rearrangement, B-Lymphocyte Humans Immunity, Humoral Immunoglobulins - genetics Immunoglobulins - immunology Immunoglobulins - metabolism Lymphocyte Activation - immunology Peyer's Patches - immunology Peyer's Patches - metabolism
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Beschreibung
Zusammenfassung:	Highlights • V(D)J recombination drives the generation of the primary immunoglobulin repertoire. • Selection forces define limits to emerging immunoglobulin diversity. • Naïve Ig repertoires are shaped by antigen encounter during B cell development. • Timing and location of early B cell development influences the naïve Ig repertoire.
ISSN:	0952-7915 1879-0372
DOI:	10.1016/j.coi.2015.02.011