Efficacy of cyclosporine combination therapy for new-onset minimal change nephrotic syndrome in adults

Background Cyclosporine and prednisolone combination therapy has been used in the treatment of minimal change nephrotic syndrome (MCNS). However, few studies have evaluated the efficacy of cyclosporine combined with intravenous methylprednisolone pulse therapy (MPT) as a first-line treatment for new-onset MCNS. We conducted a retrospective clinical study to evaluate the efficacy and safety of cyclosporine combined with MPT and oral prednisolone for new-onset MCNS in adults. Methods Forty-six adult patients with biopsy-proven MCNS were analyzed retrospectively. This study included three groups. Group 1 ( n = 17) was treated with intravenous MPT (0.5 or 1.0 g/day for 3 days) followed by oral cyclosporine (2–3 mg/kg/day) and prednisolone (30 mg/day). Group 2 ( n = 15) was treated with intravenous MPT followed by oral prednisolone (0.4–0.8 mg/kg/day). Group 3 ( n = 14) was treated with oral prednisolone (0.6–1.0 mg/kg/day) alone. Results The length of hospital stay was the shortest in Group 1 ( P